Mitochondrial p53 prompts Bak and causes disruption of a Bak-Mcl1 advanced.
- The tumour suppressor exercise of the p53 protein has been defined by its means to induce apoptosis in response to quite a lot of mobile stresses.
- Thus, understanding the mechanism by which p53 features within the execution of cell demise pathways is of appreciable significance in most cancers biology.
- Latest research have indicated that p53 has a direct signalling position at mitochondria within the induction of apoptosis, though the mechanisms concerned usually are not utterly understood.
DNA Polymerase for PAGE Enzyme
- Right here we present that, after cell stress, p53 interacts with the pro-apoptotic mitochondrial membrane protein Bak. Interplay of p53 with Bak causes oligomerization of Bak and launch of cytochrome c from mitochondria.
Guanine Nucleotide Exchange Factor For Rab-3A (RAB3IL1) Antibody
- Notably, we present that formation of the p53-Bak advanced coincides with lack of an interplay between Bak and the anti-apoptotic Bcl2-family member Mcl1. These outcomes are in step with a mannequin through which p53 and Mcl1 have opposing results on mitochondrial apoptosis by interacting with, and modulating the exercise of, the demise effector Bak.

VHL antibody |
70R-34605 |
Fitzgerald |
100 ug |
EUR 392.4 |
Description: Purified Rabbit polyclonal VHL antibody |
VHL Antibody |
32075-100ul |
SAB |
100ul |
EUR 302.4 |
VHL Antibody |
1-CSB-PA991849 |
Cusabio |
|
|
|
Description: A polyclonal antibody against VHL. Recognizes VHL from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:2000-1:10000, IHC:1:50-1:200 |
VHL Antibody |
1-CSB-PA060067 |
Cusabio |
|
|
|
Description: A polyclonal antibody against VHL. Recognizes VHL from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC:1/100-1/300.ELISA:1/40000 |
VHL Antibody |
1-CSB-PA071125 |
Cusabio |
|
|
|
Description: A polyclonal antibody against VHL. Recognizes VHL from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100 |
VHL Antibody |
1-CSB-PA876839 |
Cusabio |
|
|
|
Description: A polyclonal antibody against VHL. Recognizes VHL from Human. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC-p:1:50-300, ELISA:1:10000-20000 |
VHL Antibody |
CSB-PA025852KA01HU- |
Cusabio |
each |
EUR 402 |
|
Description: A polyclonal antibody against VHL. Recognizes VHL from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:2000, IHC:1:50-1:200 |
VHL Antibody |
CSB-PA025852KA01HU-100ul |
Cusabio |
100ul |
EUR 466.8 |
|
Description: A polyclonal antibody against VHL. Recognizes VHL from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:2000, IHC:1:50-1:200 |
VHL Antibody |
F49681-0.05ML |
NSJ Bioreagents |
0.05 ml |
EUR 140.25 |
Description: Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of VHL gene is the basis of familial inheritance of VHL syndrome. The protein is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. |
VHL Antibody |
F49681-0.2ML |
NSJ Bioreagents |
0.2 ml |
EUR 322.15 |
Description: Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of VHL gene is the basis of familial inheritance of VHL syndrome. The protein is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. |
VHL Antibody |
F49682-0.08ML |
NSJ Bioreagents |
0.08 ml |
EUR 140.25 |
Description: Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of VHL gene is the basis of familial inheritance of VHL syndrome. The protein is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. |
VHL Antibody |
F49682-0.4ML |
NSJ Bioreagents |
0.4 ml |
EUR 330.65 |
Description: Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of VHL gene is the basis of familial inheritance of VHL syndrome. The protein is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. |
VHL Antibody |
R35773-100UG |
NSJ Bioreagents |
100 ug |
EUR 339.15 |
Description: Additional name(s) for this target protein: Von Hippel-Lindau tumor suppressor, VHL1 |
anti- VHL antibody |
FNab09402 |
FN Test |
100µg |
EUR 658.5 |
|
Description: Antibody raised against VHL |
anti- VHL antibody |
FNab10175 |
FN Test |
100µg |
EUR 606.3 |
|
Description: Antibody raised against VHL |
Human VHL Antibody |
32825-05111 |
AssayPro |
150 ug |
EUR 313.2 |
VHL (pS68) Antibody |
abx219320-100ug |
Abbexa |
100 ug |
EUR 526.8 |
|
VHL Conjugated Antibody |
C32075 |
SAB |
100ul |
EUR 476.4 |
VHL Polyclonal Antibody |
46866-100ul |
SAB |
100ul |
EUR 302.4 |
VHL Polyclonal Antibody |
46866-50ul |
SAB |
50ul |
EUR 224.4 |
VHL Polyclonal Antibody |
ABP56500-003ml |
Abbkine |
0.03ml |
EUR 189.6 |
|
Description: A polyclonal antibody for detection of VHL from Human, Mouse, Rat. This VHL antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human VHL around the non-phosphorylation site of S68 |
VHL Polyclonal Antibody |
ABP56500-01ml |
Abbkine |
0.1ml |
EUR 346.8 |
|
Description: A polyclonal antibody for detection of VHL from Human, Mouse, Rat. This VHL antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human VHL around the non-phosphorylation site of S68 |
VHL Polyclonal Antibody |
ABP56500-02ml |
Abbkine |
0.2ml |
EUR 496.8 |
|
Description: A polyclonal antibody for detection of VHL from Human, Mouse, Rat. This VHL antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human VHL around the non-phosphorylation site of S68 |
VHL Polyclonal Antibody |
ABP60891-003ml |
Abbkine |
0.03ml |
EUR 189.6 |
|
Description: A polyclonal antibody for detection of VHL from Human. This VHL antibody is for IHC-P, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human VHL protein at amino acid sequence of 1-50 |
VHL Polyclonal Antibody |
ABP60891-01ml |
Abbkine |
0.1ml |
EUR 346.8 |
|
Description: A polyclonal antibody for detection of VHL from Human. This VHL antibody is for IHC-P, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human VHL protein at amino acid sequence of 1-50 |
VHL Polyclonal Antibody |
ABP60891-02ml |
Abbkine |
0.2ml |
EUR 496.8 |
|
Description: A polyclonal antibody for detection of VHL from Human. This VHL antibody is for IHC-P, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human VHL protein at amino acid sequence of 1-50 |
VHL Polyclonal Antibody |
ES7499-100ul |
ELK Biotech |
100ul |
EUR 334.8 |
Description: A Rabbit Polyclonal antibody against VHL from Human/Mouse/Rat. This antibody is tested and validated for IHC, WB, ELISA |
VHL Polyclonal Antibody |
ES7499-50ul |
ELK Biotech |
50ul |
EUR 248.4 |
Description: A Rabbit Polyclonal antibody against VHL from Human/Mouse/Rat. This antibody is tested and validated for IHC, WB, ELISA |
VHL Polyclonal Antibody |
ES8746-100ul |
ELK Biotech |
100ul |
EUR 334.8 |
Description: A Rabbit Polyclonal antibody against VHL from Human. This antibody is tested and validated for IHC, WB, ELISA |
VHL Polyclonal Antibody |
ES8746-50ul |
ELK Biotech |
50ul |
EUR 248.4 |
Description: A Rabbit Polyclonal antibody against VHL from Human. This antibody is tested and validated for IHC, WB, ELISA |
Polyclonal VHL Antibody (C-term) |
APR10723G |
Leading Biology |
0.1ml |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human VHL (C-term). This antibody is tested and proven to work in the following applications: |
Human VHL Antibody (Biotin Conjugate) |
32825-05121 |
AssayPro |
150 ug |
EUR 442.8 |
VHL (Phospho-Ser68) Antibody |
12654-100ul |
SAB |
100ul |
EUR 302.4 |
VHL (Phospho-Ser68) Antibody |
12654-50ul |
SAB |
50ul |
EUR 224.4 |
VHL (phospho Ser68) Polyclonal Antibody |
ABP56499-003ml |
Abbkine |
0.03ml |
EUR 189.6 |
|
Description: A polyclonal antibody for detection of VHL phospho Ser68) from Human, Mouse, Rat. This VHL phospho Ser68) antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human VHL around the phosphorylation site of S68 |
VHL (phospho Ser68) Polyclonal Antibody |
ABP56499-01ml |
Abbkine |
0.1ml |
EUR 346.8 |
|
Description: A polyclonal antibody for detection of VHL phospho Ser68) from Human, Mouse, Rat. This VHL phospho Ser68) antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human VHL around the phosphorylation site of S68 |
VHL (phospho Ser68) Polyclonal Antibody |
ABP56499-02ml |
Abbkine |
0.2ml |
EUR 496.8 |
|
Description: A polyclonal antibody for detection of VHL phospho Ser68) from Human, Mouse, Rat. This VHL phospho Ser68) antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human VHL around the phosphorylation site of S68 |
VHL (phospho Ser68) Polyclonal Antibody |
ES7498-100ul |
ELK Biotech |
100ul |
EUR 334.8 |
Description: A Rabbit Polyclonal antibody against VHL (phospho Ser68) from Human/Mouse/Rat. This antibody is tested and validated for IHC, WB, ELISA |
VHL (phospho Ser68) Polyclonal Antibody |
ES7498-50ul |
ELK Biotech |
50ul |
EUR 248.4 |
Description: A Rabbit Polyclonal antibody against VHL (phospho Ser68) from Human/Mouse/Rat. This antibody is tested and validated for IHC, WB, ELISA |
Von Hippel Lindau Tumor Suppressor (VHL) Antibody |
20-abx210322 |
Abbexa |
|
|
|
Von Hippel Lindau Tumor Suppressor (vHL) Antibody |
20-abx175113 |
Abbexa |
|
|
|
Von Hippel Lindau Tumor Suppressor (VHL) Antibody |
20-abx211119 |
Abbexa |
|
|
|
Von Hippel Lindau Tumor Suppressor (VHL) Antibody |
20-abx326550 |
Abbexa |
|
|
|
Von Hippel Lindau Tumor Suppressor (vHL) Antibody |
20-abx131162 |
Abbexa |
-
EUR 543.60
-
EUR 159.60
-
EUR 1562.40
-
EUR 744.00
-
EUR 410.40
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
Von Hippel Lindau Tumor Suppressor (VHL) Antibody |
20-abx323201 |
Abbexa |
|
|
|
Monoclonal VHL Antibody (monoclonal) (M01), Clone: 1G12 |
APR10724G |
Leading Biology |
0.1mg |
EUR 580.8 |
Description: A Monoclonal antibody against Human VHL (monoclonal) (M01). The antibodies are raised in mouse and are from clone 1G12. This antibody is applicable in WB and IF, E |
Human VHL AssayLite Antibody (RPE Conjugate) |
32825-05151 |
AssayPro |
150 ug |
EUR 513.6 |
Human VHL AssayLite Antibody (APC Conjugate) |
32825-05161 |
AssayPro |
150 ug |
EUR 513.6 |
Human VHL AssayLite Antibody (FITC Conjugate) |
32825-05141 |
AssayPro |
150 ug |
EUR 513.6 |
Human VHL AssayLite Antibody (PerCP Conjugate) |
32825-05171 |
AssayPro |
150 ug |
EUR 565.2 |
Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody |
20-abx137392 |
Abbexa |
-
EUR 844.80
-
EUR 393.60
-
EUR 276.00
|
|
|
Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody |
abx239402-100ug |
Abbexa |
100 ug |
EUR 610.8 |
|
Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody |
abx219331-100ug |
Abbexa |
100 ug |
EUR 526.8 |
|
Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody |
abx117007-100ug |
Abbexa |
100 ug |
EUR 560.4 |
|
Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody |
abx032864-400ul |
Abbexa |
400 ul |
EUR 627.6 |
|
Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody |
abx032864-80l |
Abbexa |
80 µl |
EUR 343.2 |
|
Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody |
abx032865-400ul |
Abbexa |
400 ul |
EUR 627.6 |
|
Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody |
abx032865-80l |
Abbexa |
80 µl |
EUR 343.2 |
|
Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody |
20-abx126781 |
Abbexa |
-
EUR 493.20
-
EUR 710.40
-
EUR 218.40
-
EUR 376.80
|
- 100 ul
- 200 ul
- 20 ul
- 50 ul
|
|
Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody |
abx125410-50ul |
Abbexa |
50 ul |
EUR 427.2 |
|
Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody |
abx431703-200ul |
Abbexa |
200 ul |
EUR 460.8 |
|
Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody |
20-abx000699 |
Abbexa |
-
EUR 493.20
-
EUR 710.40
-
EUR 218.40
-
EUR 376.80
|
- 100 ul
- 200 ul
- 20 ul
- 50 ul
|
|
Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody |
abx012353-100ug |
Abbexa |
100 ug |
EUR 526.8 |
|
VHL (Phospho-Ser68) Polyclonal Conjugated Antibody |
C12654 |
SAB |
100ul |
EUR 476.4 |
Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody (Biotin) |
abx431704-200ul |
Abbexa |
200 ul |
EUR 460.8 |
|
Anti-VHL antibody |
STJ113440 |
St John's Laboratory |
50 µl |
EUR 332.4 |
Description: Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. |
Anti-VHL antibody |
STJ113742 |
St John's Laboratory |
100 µl |
EUR 332.4 |
Description: Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. |
Anti-VHL antibody |
STJ26089 |
St John's Laboratory |
100 µl |
EUR 332.4 |
Description: Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. |
Anti-VHL antibody |
STJ96241 |
St John's Laboratory |
200 µl |
EUR 236.4 |
Description: Rabbit polyclonal to VHL. |
SirT3 suppresses hypoxia inducible issue 1α and tumor development by inhibiting mitochondrial ROS manufacturing.
- The position of oncoproteins and tumor suppressor proteins in selling the malignant transformation of mammalian cells by affecting properties reminiscent of proliferative signalling, cell cycle regulation and altered adhesion is effectively established.
Taq DNA Polymerase (Recombinant)
- Chemical compounds, viruses and radiation are additionally typically accepted as brokers that generally induce mutations within the genes encoding these most cancers-causing proteins, thereby giving rise to most cancers. Nevertheless, more moderen proof signifies the significance of two advertditional key components imposed on proliferating cells which can be concerned in transformation to malignancy and these are hypoxia and/or aggravating circumstances of nutrient deprivation (e.g. lack of glucose).
- These two further triggers can provoke and promote the method of malignant transformation when a low share of cells overcome and escape mobile senescence. It’s turning into obvious that hypoxia causes the progressive elevation in mitochondrial ROS production (continual ROS) which over time results in stabilization of cells through elevated HIF-2alpha expression, enabling cells to outlive with sustained ranges of elevated ROS.
Recombination Signal Binding Protein For Immunoglobulin Kappa J Region (RBPJ) Antibody
- In cells below hypoxia and/or low glucose, DNA mismatch restore processes are repressed by HIF-2alpha and so they frequently accumulate mitochondrial ROS-induced oxidative DNA injury and rising numbers of mutations driving the malignant transformation course of.
- Latest proof additionally signifies that the ensuing mutated most cancers-causing proteins suggestions to amplify the method by immediately affecting mitochondrial operate in combinatorial ways in which intersect to play a serious position in selling a vicious spiral of malignant cell transformation.
- Consequently, many malignant course ofes contain intervals of elevated mitochondrial ROS manufacturing when a number of cells survive the extra frequent technique of oxidative injury induced cell senescence and demise. The few cells escaping elimination emerge with oncogenic mutations and survive to change into immortalized tumors.
- This evaluation focuses on evidence highlighting the position of mitochondria as drivers of elevated ROS manufacturing throughout malignant transformation and therefore, their potential as targets for most cancers remedy. The evaluation is organized into 5 fundamental sections regarding totally different features of “mitochondrial malignancy”.
- The primary considerations the features of mitochondrial ROS and its significance as a pacesetter for cell development versus senescence and demise. The second considers the obtainable proof that mobile stress within the type of hypoxic and/or hypoglycaemic conditions signify two of the main triggering occasions for most cancers and the way oncoproteins reinforce this course of by altering gene expression to deliver a couple of frequent set of modifications in mitochondrial operate and exercise in most cancers cells.
- The third part presents proof that oncoproteins and tumor suppressor proteins bodily localize to the mitochondria in most cancers cells the place they immediately regulate malignant mitochondrial packages, together with apoptosis.
- The fourth part covers frequent mutational modifications within the mitochondrial genome as they relate to malignancy and the connection to the opposite three areas. The final part considerations the relevance of those findings, their significance and significance for novel focused approaches to anti–most cancers remedy and selective triggering in most cancers cells of the mitochondrial apoptotic pathway.
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